- Semaglutide

For Type 2 Diabetes

• Initial Dose: Start with 0.25 mg injected subcutaneously once a week for 4 weeks.
• Following Doses: After the initial period, the dose can be increased based on the doctor's recommendation, typically up to a maximum of 2 mg once a week.

For Chronic Weight Management

• Starting Dose: Begin with 0.25 mg once a week.
• Dose Escalation: Increase the dose gradually every four weeks—0.5 mg, 1 mg, 1.7 mg, up to a maintenance dose of 2.4 mg once weekly.

• Administration Notes

• Semaglutide should be administered subcutaneously in the abdomen, thigh, or upper arm, using a pre-filled pen. It's recommended to inject at any time of day, without regard to meals. If a dose is missed, it should be taken as soon as possible if within a certain timeframe (5 days ), otherwise, skip the dose and return to the regular schedule​

Administration Notes

• Semaglutide should be administered subcutaneously in the abdomen, thigh, or upper arm, using a pre-filled pen. It's recommended to inject at any time of day, without regard to meals. If a dose is missed, it should be taken as soon as possible if within a certain timeframe (5 days for Ozempic® and Wegovy®, and 2 days for Rybelsus®), otherwise, skip the dose and return to the regular schedule​

- Tirzepatide

Tirzepatide combines the effects of GIP and GLP-1, both incretin hormones. These hormones are released in response to food intake and stimulate pancreatic beta cells to secrete insulin. GIP also plays a role in nutrient and energy metabolism, while GLP-1 has additional effects such as delaying gastric emptying and suppressing appetite, which aids in glycemic control and weight reduction.

Week	Dose of Tirzepatide
1-4	2.5 mg once weekly
5-8	5 mg once weekly
9-12	7.5 mg once weekly (if needed)
13+	Up to 15 mg once weekly (if needed)

This regimen starts with a lower dose to minimize side effects, with potential increases every 4 weeks based on the need for further glycemic control.